Human Chorionic Gonadotropin — LH Mimetic for Testicular Function & PCT
HCG (Human Chorionic Gonadotropin) is a glycoprotein hormone that mimics luteinizing hormone (LH). In the context of hormone optimization, it is used to maintain testicular function during anabolic cycles and as the first step in post-cycle therapy (PCT) to restore endogenous testosterone production.
Binds to LH receptors on Leydig cells in the testes, stimulating intratesticular testosterone production and maintaining testicular volume. This prevents the testicular atrophy and shutdown that occurs during exogenous androgen use, and primes the HPTA for recovery during PCT.
| Parameter | Details |
|---|---|
| On-Cycle Maintenance | 250–500 IU 2–3x/week |
| PCT Kick-Start | 500–1,000 IU EOD for 1–2 weeks |
| PCT Timing | Begin post last steroid injection, before SERM |
| Route | Subcutaneous injection (31G insulin syringe) |
| Reconstitution | Bacteriostatic water, 1–2 mL per vial |
| Storage | Refrigerate after reconstitution — 30-day potency window |
Must Follow With SERM
HCG is HPTA-suppressive on its own. It must always be followed by a SERM (e.g., Enclomiphene) to complete PCT. Running HCG alone without transitioning to a SERM will not restore the hypothalamic-pituitary axis.
Estrogen Management Required
HCG stimulates intratesticular testosterone which aromatizes to estrogen. Monitor for gyno symptoms and have an AI (e.g., Exemestane) on hand. Do not run high-dose HCG without estrogen management.
This guide is for educational and clinical-support purposes only. All dosing must be supervised by a licensed prescriber. Matrix Advanced Solutions does not provide medical advice. Always consult your healthcare provider before starting any peptide protocol.