Lys-Pro-Val — Anti-Inflammatory Peptide for Gut Mucosa Healing & IBD Support
KPV (Lysine-Proline-Valine) is a naturally occurring tripeptide derived from alpha-melanocyte-stimulating hormone (alpha-MSH). It is a potent anti-inflammatory agent with particular affinity for the gut mucosa, making it a key peptide for inflammatory bowel conditions and systemic inflammation management.
Lowers pro-inflammatory cytokines including TNF-alpha and inhibits NF-kB signaling in gut epithelial and immune cells. By suppressing these inflammatory cascades, KPV reduces mucosal inflammation, supports gut barrier integrity, and promotes tissue healing in the gastrointestinal tract.
| Parameter | Details |
|---|---|
| Starting Dose | 250 mcg daily |
| Moderate Dose | 500 mcg daily |
| High Dose | 1,000 mcg daily |
| Route | Subcutaneous injection or oral capsule |
| Cycle Length | 4–8 weeks |
| Onset | Gut symptom improvement typically within 1–2 weeks |
Review Required — Solo Protocol
Solo dosing data for KPV has been extracted from the KLOW stack guide. No standalone PDF exists for this peptide. Solo protocol confirmation is pending review. Use stack-validated dosing ranges until confirmed.
Clinical Note
KPV is considered one of the safer anti-inflammatory peptides. Oral bioavailability is acceptable for gut-targeted effects, though SubQ may provide more reliable systemic anti-inflammatory action.
This guide is for educational and clinical-support purposes only. All dosing must be supervised by a licensed prescriber. Matrix Advanced Solutions does not provide medical advice. Always consult your healthcare provider before starting any peptide protocol.