GHRH analog that stimulates pituitary GH release — one of the original growth hormone secretagogues.
Sermorelin is a GHRH analog that signals the pituitary gland to release growth hormone. It is one of the original GH secretagogues and is often used as part of anti-aging and recovery protocols. It can be paired with GHK-Cu for a combined collagen/skin + GH protocol.
Sermorelin acts on the GHRH receptor in the anterior pituitary, stimulating the natural synthesis and release of endogenous growth hormone. As one of the earliest GHRH analogs developed, it has a well-characterized safety profile and remains a foundational compound in GH optimization protocols.
| Tier | Dose | Frequency | Notes |
|---|---|---|---|
| Starting | 100–250 mcg | Nightly (before bed, fasted) | Begin here to assess tolerance |
| Moderate | 250–300 mcg | Nightly | Standard protocol dose |
| High | 500 mcg – 2 mg | Nightly | Advanced — monitor IGF-1 |
Schedule: 5 days on, 2 days off
Cycle Length: 12–24 weeks + 4–8 week washout
Route: Subcutaneous injection, fasted, before bed
Monitor IGF-1 levels at 6 weeks and adjust dose accordingly. If IGF-1 is elevated above range, reduce dose or pause the protocol.