CJC-1295 (DAC & No-DAC)

GHRH analog that signals the pituitary to release endogenous GH — available in sustained-release (DAC) and pulsatile (No-DAC) variants.

VIAL IMAGE NEEDED

What It Is

CJC-1295 is a growth hormone-releasing hormone (GHRH) analog that tells your pituitary gland to release its own growth hormone. It comes in two variants: CJC-1295 with DAC (Drug Affinity Complex) provides sustained GH elevation with weekly dosing, while CJC-1295 No-DAC (also called Mod GRF 1-29) produces natural pulsatile GH release with daily injections.

Mechanism of Action

CJC-1295 acts on the GHRH receptor in the pituitary gland, stimulating the release of endogenous growth hormone. The DAC version binds to albumin in the bloodstream, extending its half-life and producing sustained GH elevation over days. The No-DAC version has a short half-life, mimicking the body's natural pulsatile GH rhythm.

Key Benefits

Sustained GH elevation (DAC)

Natural GH pulsing (No-DAC)

Enhanced recovery

Fat loss support

IGF-1 elevation

Improved sleep quality

Dosing Protocol — CJC-1295 with DAC

Tier	Dose	Frequency	Notes
Starting	13 mcg/lb	Once weekly	Example: 180 lb = ~2.3 mg/week
Moderate	27 mcg/lb	Once weekly	Example: 180 lb = ~4.9 mg/week

Route: Subcutaneous injection

Cycle Length: 8–12 weeks

Dosing Protocol — CJC-1295 No-DAC (Mod GRF 1-29)

Tier	Dose	Frequency	Notes
Starting	100 mcg	Once daily (bedtime)	Begin here to assess tolerance
Moderate	200 mcg	2x daily (AM + pre-bed)	Standard protocol
High	200 mcg	3x daily (AM + pre-training + pre-bed)	Advanced — monitor IGF-1

Cycle Length: 8–12 weeks

Route: Subcutaneous injection

Best paired with: Ipamorelin (GHRH + GHS synergy)

Administration & Reconstitution

Reconstitution: BAC water, 1–2 mL per vial
Needle: 31G insulin syringe, subcutaneous
Storage: Refrigerate after reconstitution

Protocol Notes

Do NOT stack two GHRH analogs (e.g., CJC-1295 + Sermorelin). They act on the same receptor — there is no added benefit, only increased side-effect risk.

DAC version is better for convenience (weekly injection)
No-DAC version is better for preserving natural GH pulsatility
Administer fasted — insulin suppresses GH release

Safety & Side Effects

Possible side effects:

Water retention and bloating
Tingling or numbness
Injection site redness

Long-term risks mirror those of sustained GH elevation. Monitor IGF-1 levels at 6 weeks and adjust dose accordingly.